Multiple Autoimmune Syndrome (MAS) is what I am dealing with:

Not able to post today as rest is only way to lower symptoms. I've had this since 1996 and it's progressive so... I'm doing great considering

Multiple Autoimmune Syndrome (MAS) is the coexistence of at least three distinct autoimmune diseases in a single patient, often featuring a mix of organ-specific and systemic disorders, with a high prevalence of skin-related conditions like vitiligo or psoriasis. It represents a severe, complex form of polyautoimmunity, requiring careful monitoring to identify new, additional autoimmune disorders.

Key Aspects of Multiple Autoimmune Syndrome (MAS)

• Definition & Types: MAS is classified into three main, sometimes overlapping, categories based on common co-occurrences:
  • Type 1: Often includes myasthenia gravis, thymoma, polymyositis, and giant cell myocarditis.
  • Type 2: Commonly includes Sjögren’s syndrome, rheumatoid arthritis (RA), primary biliary cirrhosis, scleroderma, and autoimmune thyroid disease.
  • Type 3: Often includes autoimmune thyroid diseases, myasthenia gravis, thymoma, and other conditions like type 1 diabetes, and is sometimes associated with HLA-B8, -DR3, or -DR5.
• Common Symptoms: Symptoms are heterogeneous, reflecting the specific diseases present, but generally include chronic fatigue, joint pain, skin changes, muscular weakness, digestive issues, and signs of organ dysfunction.
• Causes & Risk Factors: The pathogenesis is not fully understood, but it is believed to involve a combination of genetic susceptibility, immune system dysfunction (loss of tolerance to self-antigens), and environmental triggers.
• Diagnosis & Management: Diagnosis is clinical, based on identifying at least three separate autoimmune diseases. Management often involves specialized care to manage multiple conditions, including medications like corticosteroids and immunosuppressants, such as Anakinra.
• Prevalence: While individual autoimmune diseases are common, having three or more is less common, but the presence of one autoimmune condition increases the risk for developing others.

Early Signs of Multiple Autoimmune Syndrome
Early signs to watch for, especially in patients already diagnosed with one autoimmune disease, include: 

• Unexplained, persistent fatigue.
• New, unexpected joint pain or swelling.
• Skin rashes or pigment changes (e.g., vitiligo, psoriasis).
• Unexplained weight loss or gain.
• Chronic digestive issues.
• Unusual muscle weakness. 

-ke: Copy pasted from Google AI